KEGG   Drosophila melanogaster (fruit fly): Dmel_CG10223
Entry
Dmel_CG10223      CDS       T00030                                 
Symbol
Top2
Name
(RefSeq) topoisomerase 2, isoform B
  KO
K03164  DNA topoisomerase II [EC:5.6.2.2]
Organism
dme  Drosophila melanogaster (fruit fly)
Brite
KEGG Orthology (KO) [BR:dme00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:dme03032]
    Dmel_CG10223 (Top2)
   03036 Chromosome and associated proteins [BR:dme03036]
    Dmel_CG10223 (Top2)
Enzymes [BR:dme01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.2  DNA topoisomerase (ATP-hydrolysing)
     Dmel_CG10223 (Top2)
DNA replication proteins [BR:dme03032]
 Eukaryotic type
  DNA Topoisomerases
   Dmel_CG10223 (Top2)
Chromosome and associated proteins [BR:dme03036]
 Eukaryotic type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    Dmel_CG10223 (Top2)
  Centrosome formation proteins
   Centriole proteins
    Dmel_CG10223 (Top2)
SSDB
Motif
Pfam: DNA_topoisoIV TOPRIM_C DNA_gyraseB Toprim HATPase_c RE_ApaLI
Other DBs
NCBI-GeneID: 35225
NCBI-ProteinID: NP_001260580
FlyBase: FBgn0284220
UniProt: P15348
Position
2L
AA seq 1447 aa
MENGNKALSIEQMYQKKSQLEHILLRPDSYIGSVEFTKELMWVYDNSQNRMVQKEISFVP
GLYKIFDEILVNAADNKQRDKSMNTIKIDIDPERNMVSVWNNGQGIPVTMHKEQKMYVPT
MIFGHLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTSFTVETATREYKKSFKQTWGNNMG
KASDVQIKDFNGTDYTRITFSPDLAKFKMDRLDEDIVALMSRRAYDVAASSKGVSVFLNG
NKLGVRNFKDYIDLHIKNTDDDSGPPIKIVHEVANERWEVACCPSDRGFQQVSFVNSIAT
YKGGRHVDHVVDNLIKQLLEVLKKKNKGGINIKPFQVRNHLWVFVNCLIENPTFDSQTKE
NMTLQQKGFGSKCTLSEKFINNMSKSGIVESVLAWAKFKAQNDIAKTGGRKSSKIKGIPK
LEDANEAGGKNSIKCTLILTEGDSAKSLAVSGLGVIGRDLYGVFPLRGKLLNVREANFKQ
LSENAEINNLCKIIGLQYKKKYLTEDDLKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTN
WPELLRLPFLEEFITPIVKATKKNEELSFYSLPEFEEWKNDTANHHTYNIKYYKGLGTST
SKEAKEYFQDMDRHRILFKYDGSVDDESIVMAFSKKHIESRKVWLTNHMDEVKRRKELGL
PERYLYTKGTKSITYADFINLELVLFSNADNERSIPSLVDGLKPGQRKVMFTCFKRNDKR
EVKVAQLSGSVAEMSAYHHGEVSLQMTIVNLAQNFVGANNINLLEPRGQFGTRLSGGKDC
ASARYIFTIMSPLTRLIYHPLDDPLLDYQVDDGQKIEPLWYLPIIPMVLVNGAEGIGTGW
STKISNYNPREIMKNLRKMINGQEPSVMHPWYKNFLGRMEYVSDGRYIQTGNIQILSGNR
LEISELPVGVWTQNYKENVLEPLSNGTEKVKGIISEYREYHTDTTVRFVISFAPGEFERI
HAEEGGFYRVFKLTTTLSTNQMHAFDQNNCLRRFPTAIDILKEYYKLRREYYARRRDFLV
GQLTAQADRLSDQARFILEKCEKKLVVENKQRKAMCDELLKRGYRPDPVKEWQRRIKMED
AEQADEEDEEEEEAAPSVSSKAKKEKEVDPEKAFKKLTDVKKFDYLLGMSMWMLTEEKKN
ELLKQRDTKLSELESLRKKTPEMLWLDDLDALESKLNEVEEKERAEEQGINLKTAKALKG
QKSASAKGRKVKSMGGGAGAGDVFPDPDGEPVEFKITEEIIKKMAAAAKVAQAAKEPKKP
KEPKEPKVKKEPKGKQIKAEPDASGDEVDEFDAMVEGGSKTSPKAKKAVVKKEPGEKKPR
QKKENGGGLKQSKIDFSKAKAKKSDDDVEEVTPRAERPGRRQASKKIDYSSLFSDEEEDG
GNVGSDDDGNASDDDSPKRPAKRGREDESSGGAKKKAPPKKRRAVIESDDDDIEIDEDDD
DDSDFNC
NT seq 4344 nt   +upstreamnt  +downstreamnt
atggagaacggaaacaaggccctgtccatcgaacagatgtaccagaagaagtcgcagctg
gagcacatcctgctgcgacccgactcgtacatcggatccgtggagttcaccaaggagctg
atgtgggtgtatgacaactcccaaaaccgcatggtgcagaaggagatctctttcgtgccc
ggcctctacaagatattcgacgagattcttgtgaatgcggcagataacaagcagcgagac
aagagcatgaacaccattaagatcgacatcgatccggagcgcaatatggtgtccgtgtgg
aacaacggccagggcattccggtgaccatgcacaaggagcagaagatgtacgttccaacg
atgatctttggtcatctgctgacctcgtcgaactacaacgacgatgagaagaaggtcact
ggcggcaggaacggatacggagcgaagctctgcaacatattctccaccagcttcaccgtt
gagactgccacgagggaatacaagaaaagtttcaagcagacttggggaaacaacatggga
aaagcctccgatgtgcagatcaaggacttcaatggcactgactacacacgcatcacattc
agtcccgatctggccaagttcaagatggaccgtctcgatgaagatattgtggctctaatg
tcgcgtcgcgcctacgatgtggccgcctcatccaagggagtatccgtcttcttaaacggc
aacaaactgggtgtacgcaacttcaaggactatattgatttgcacatcaagaacacggac
gacgattctggcccaccgatcaagatagtccacgaggttgccaacgagcgttgggaggtg
gcttgctgtccttcagatcgaggcttccaacaggtctcgtttgtcaactcgatagctacc
tacaagggcggtcggcatgtggaccatgtggtagacaatctcattaagcagctgctcgag
gttctgaagaaaaagaacaaaggtggcatcaacatcaagccattccaggtccgaaaccat
ctgtgggtttttgtcaactgcttgatagagaaccccactttcgactcgcagaccaaggag
aacatgactctgcaacaaaagggcttcggttccaagtgtaccctctcggaaaagttcatc
aacaacatgtccaagtctggcatcgtggagtctgtgctggcatgggccaagttcaaggcc
caaaatgacattgccaagacgggcggtcgcaagtcaagcaagatcaagggcattcccaag
ctggaggacgctaacgaggcgggtggaaagaactcgattaaatgcaccctcatcctcacc
gagggagactcagccaagtcattggccgtatccggtttgggcgtgatcggacgagatctc
tacggcgtgttcccgcttaggggtaaacttctaaatgtgcgggaagctaatttcaagcag
ctttcggagaatgccgaaatcaacaatttatgcaagataattggcttgcaatacaaaaag
aagtacctcactgaggacgatctaaaaactctgcgctatggcaaagtgatgatcatgaca
gatcaggatcaggatggctcccacatcaagggtctcttgatcaactttatccacaccaat
tggccagagcttctgcgtctgcccttcctcgaggagttcattacaccaattgtgaaggca
accaagaaaaacgaggagctgtcattctactcgctacccgaattcgaggagtggaaaaat
gatacagctaatcaccatacgtacaatataaagtactataagggtttgggtacttcgacc
tccaaggaggcgaaagagtattttcaagacatggatcgccatcgcatcttatttaagtac
gatggatcggtggatgatgagagcattgttatggccttctccaagaagcacatcgagtcg
cgaaaggtatggcttaccaaccacatggacgaggtgaagcgtcgcaaggagctcggtttg
ccagagcgatatctctacaccaagggcaccaagagcatcacctatgcagactttatcaat
ctggagttggtgctgttctcgaatgctgacaatgagcgctccattcctagtctggtggat
ggcttgaagccgggtcagcggaaggtgatgttcacttgcttcaagaggaatgacaagcgt
gaggtgaaggtggcccagctatccggatcagtggcggagatgtcagcctatcaccacgga
gaggtatccctacagatgacaatcgtgaatctggctcagaattttgtgggtgccaacaac
attaatctgcttgagccacgcggtcaatttggtacccgcttgtcgggaggcaaagattgc
gccagcgctcgttacattttcactataatgtctcccttgacgcgactcatctaccatcct
ttggacgatccacttttggattaccaggtggacgatggccaaaagatcgagccactatgg
tatctgcccatcataccgatggtattggtaaacggagccgagggcataggaactggatgg
tccacgaagatatccaactacaatcctcgtgagattatgaaaaatctaaggaagatgata
aacggacaagagccaagtgtgatgcatccgtggtacaagaactttttaggacgcatggag
tatgtttcggatggtcgttatattcagactggtaacattcaaattttgtccggaaaccgt
ttagaaatcagtgaactccctgtgggcgtatggacgcaaaactacaaggaaaatgtcctg
gagcctttatcaaacggcaccgaaaaggttaagggtattatttccgagtacagggagtat
catacagacaccaccgttcgctttgtgatcagtttcgcacctggagaatttgagcgcatt
catgcagaagaaggtggtttctaccgagtgttcaaacttaccacgacgctgtccaccaac
cagatgcatgcgttcgaccagaacaactgtctgcgacgcttccccaccgcgatcgatatc
cttaaagagtattacaaactgcgacgagagtactacgcccgccggagggactttttggtc
ggccagctcacggcgcaggctgatcgcctcagtgatcaggcgcgctttattctcgaaaag
tgtgagaagaagctggtggtggagaacaagcagcgcaaggccatgtgtgatgagttgttg
aagcgtggatatcgtcccgatcccgtcaaggagtggcagcgccgcattaaaatggaggat
gccgagcaagctgacgaagaggacgaagaagaagaggaggcagctcccagtgtcagctca
aaggctaagaaggaaaaggaagtcgatccggaaaaggcctttaagaaactaactgatgtc
aaaaagtttgactaccttctgggtatgtccatgtggatgttgacagaggagaagaaaaac
gagctactcaaacagcgcgacactaaactgtccgagttggaaagtctgcgcaagaagacg
ccggagatgctttggctggatgatttggatgccctcgaatcgaagttaaatgaagtagag
gagaaggagcgcgcagaagagcaggggatcaatctcaagaccgcgaaggctttgaagggc
cagaagtcggcctcagctaagggcagaaaggttaagtcaatgggaggcggagcgggtgcc
ggagacgtattcccagatcccgatggagaacccgtcgagtttaagatcaccgaagaaatc
attaagaaaatggcagcggctgccaaggtagctcaggcggctaaggagccgaagaaaccc
aaagagcccaaggagccaaaagtgaagaaggaaccgaagggcaagcagattaaagccgaa
cctgatgccagcggcgatgaggtggacgaatttgatgcaatggtcgagggcggctctaag
acctcacccaaggccaagaaggcggttgtcaagaaggagccgggagaaaaaaagccgcgc
caaaagaaggagaacggcggcgggctcaagcagagcaagattgacttcagcaaggccaag
gcgaaaaagagcgacgatgacgtggaggaagtaactcctcgtgcagagcgtcctggacgt
cgacaggccagtaagaagatagactacagctcgctcttctcggatgaggaggaagacggt
ggcaacgttggctctgatgatgatggcaatgccagcgatgatgattcgcccaagcgtcca
gctaagcgtggacgagaggatgagagcagtggaggagccaaaaagaaagctccgcccaag
aagaggcgagctgtaattgaaagcgatgatgatgatatcgagattgatgaagatgatgat
gatgattctgattttaattgttaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (70)   
   KEGG ORTHOLOGY (1)   
   RefGene (65)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   FLYBASE (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (6)   
   Pfam (6)   
All databases (88)   

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